What are the characteristics and results of Tilt Tests in the elderly?
DOI:
https://doi.org/10.24207/jca.v38i.3491Keywords:
Tilt-Table Test, Vasovagal Syncope, AgedAbstract
Introduction: The elderly have several causes of syncope or pre-syncope. The importance of the Tilt Test (TT) has been questioned in this population. However, dysautonomic causes are common in these age groups, having an impact on morbidity and mortality. Objective: Compare the results of the TT between the age groups of the elderly (>=60 years) and the non-elderly. Methods: Crosssectional study carried out between 2016-2021. We used the Mann-Whitney and Chi-square tests, with a p-value < 5% considered significant. The protocols used were Westminster or Italian. Results: We analyzed 2364 tilt tests, 61.7% female, aged 51.1 (31-71) years. Positivity was 32.6%, 37.2% with sensitization (p < 0.0001). In the elderly group (EG), there were 958 tests (40.5%) and 1381 (58.4%) in the non-elderly (NEG). EG positivity was 270 (28.0%), lower than NEG with 524 (37.43%) (p < 0.01). Positivity with sensitization in EG was 195 (20.35%) x 403(29.18%) in NEG (p<0.001). In EG, 50 patients (5.22%) had a dysautonomic response and in NEG, there were 10 (0.72%) (p < 0.001). Complications were 4.2% EG x 2.6% NEG ( p= 0.03). Conclusion: The TT in the elderly showed a lower incidence of positivity in the passive and sensitization phases compared to the non-elderly. Vasovagal causes were the most frequent causes in the elderly, had a higher incidence of dysautonomic responses, fewer prodromes and a higher rate of complications, however without severity.
Downloads
References
Natale A, Sra J, Akhtar M, Kusmirek L, Tomassoni G, Leonelli F, et al. Use of sublingual nitroglycerin during head-up tilt-table testing in patients> 60 years of age. The American journal of cardiology. 1998;82(10):1210-1213. https://doi.org/10.1016/s0002-9149(98)00606-7 DOI: https://doi.org/10.1016/S0002-9149(98)00606-7
Shen WK, Sheldon RS, Benditt DG, Cohen MI, Forman DE, Goldberger ZD, et al. 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Circulation. 2017;136(5):e60–122. https://doi.org/10.1161/cir.0000000000000499 DOI: https://doi.org/10.1161/CIR.0000000000000537
Freeman R. Clinical practice. Neurogenic orthostatic hypotension. N Engl J Med. 2008;358(6):615–24. https://doi.org/10.1056/nejmcp074189 DOI: https://doi.org/10.1056/NEJMcp074189
Pop-Busui R, Evans GW, Gerstein HC, Fonseca V, Fleg JL, Hoogwerf BJ, et al. Effects of cardiac autonomic dysfunction on mortality risk in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. Diabetes Care. 2010;33(7):1578–84. https://doi.org/10.2337/dc10-0125 DOI: https://doi.org/10.2337/dc10-0125
Rocha EA, Mehta N, Távora-Mehta MZP, Roncari CF, Cidrão AA de L, Elias Neto J. Dysautonomia: A Forgotten Condition - Part 1. Arq Bras Cardiol. 2021;116(4):814–35. https://doi.org/10.36660/abc.20200420 DOI: https://doi.org/10.36660/abc.20200420
Macedo PG, Leite LR, Santos-Neto L, Hachul D. Teste de inclinação (Tilt-test): do necessário ao imprescindível. Arq. Bras. Cardiol. 2011;96(3):246-254. https://doi.org/10.1590/S0066-782X2011005000006 DOI: https://doi.org/10.1590/S0066-782X2011005000006
Brignole M, Moya A, de Lange FJ, Deharo J, Elliott PM, Fanciulli A, et al. 2018 ESC Guidelines for the diagnosis and management of syncope. European Heart Journal. 2018;8(21):1883–1948. https://doi.org/10.1093/eurheartj/ehy037 DOI: https://doi.org/10.5603/KP.2018.0161
Rocha EA, Mehta N, Távora-Mehta MZP, Roncari CF, Cidrão AA de L, Elias Neto J. Dysautonomia: A Forgotten Condition - Part II. Arq Bras Cardiol. 2021;116(5):981–98. https://doi.org/10.36660/abc.20200422 DOI: https://doi.org/10.36660/abc.20200422
Brignole M, Menozzi C, Del Rosso A, Costa S, Gaggioli G, Bottoni N, et al. New classification of haemodynamics of vasovagal syncope: beyond the VASIS classification. Analysis of the pre-syncopal phase of the tilt test without and with nitroglycerin challenge. Vasovagal Syncope International Study. Europace. 2000;2(1):66–76. https://doi.org/10.1053/eupc.1999.0064 DOI: https://doi.org/10.1053/eupc.1999.0064
Barón-Esquivias G, Cayuela A, Pedrote A, Cabezón S, Morán JE, Errázquin F. Clinical characteristics and head-up tilt test results with three protocols in 1661 patients with syncope. Rev Esp Cardiol. 2003;56(9): 916-20. https://doi.org/10.1016/s0300-8932(03)76981-4 DOI: https://doi.org/10.1157/13051620
Rocha EA. Síndromes neuralmente mediadas. Arquivos Brasileiros de Cardiologia. 2006; 87(3):e34-e44. https://doi.org/10.1590/S0066-782X2006001600032 DOI: https://doi.org/10.1590/S0066-782X2006001600032
Tan MP, Parry SW. Vasovagal syncope in the older patient. J Am Coll Cardiol. 2008;51(6):599–606. https://doi.org/10.1016/j.jacc.2007.11.025 DOI: https://doi.org/10.1016/j.jacc.2007.11.025
Romme JJCM, van Dijk N, Boer KR, Dekker LRC, Stam J, Reitsma JB, et al. Influence of age and gender on the occurrence and presentation of reflex syncope. Clin Auton Res. 2008;18(3):127–133. https://doi.org/10.1007/s10286-008-0465-0 DOI: https://doi.org/10.1007/s10286-008-0465-0
van Dijk JG, van Rossum IA, van Houwelingen M, Ghariq M, Saal DP, de Lange FJ, et al. Influence of Age on Magnitude and Timing of Vasodepression and Cardioinhibition in Tilt-Induced Vasovagal Syncope. JACC Clin Electrophysiol. 2022;8(8):997–1009. https://doi.org/10.1016/j.jacep.2022.05.009 DOI: https://doi.org/10.1016/j.jacep.2022.05.009
Kochiadakis GE, Papadimitriou EA, Marketou ME, Chrysostomakis SI, Simantirakis EN, Vardas PE. Autonomic nervous system changes in vasovagal syncope: is there any difference between young and older patients? Pacing Clin Electrophysiol. 2004;27(10):1371–7. https://doi.org/10.1111/j.1540-8159.2004.00641.x DOI: https://doi.org/10.1111/j.1540-8159.2004.00641.x
Kenny RA, O’Shea D, Parry SW. The Newcastle protocols for head-up tilt table testing in the diagnosis of vasovagal syncope, carotid sinus hypersensitivity, and related disorders. Heart. 2000;83(5):564–9. https://doi.org/10.1136/heart.83.5.564 DOI: https://doi.org/10.1136/heart.83.5.564
Parry SW, Reeve P, Lawson J, Shaw FE, Davison J, Norton M, et al. The Newcastle protocols 2008: an update on head-up tilt table testing and the management of vasovagal syncope and related disorders. Heart. 2009;95(5):416–20. https://doi.org/10.1136/hrt.2007.136457 DOI: https://doi.org/10.1136/hrt.2007.136457
Sutton R, Ricci F, Fedorowski A. Risk stratification of syncope: Current syncope guidelines and beyond. Auton Neurosci. 2021;238:102929. https://doi.org/10.1016/j.autneu.2021.102929 DOI: https://doi.org/10.1016/j.autneu.2021.102929
Brignole M, Benditt DG. Syncope: An Evidence-Based Approach. Springer Nature; 2020. 343 p. DOI: https://doi.org/10.1007/978-3-030-44507-2
Brignole M, Menozzi C, Bartoletti A, Giada F, Lagi A, Ungar A, et al. A new management of syncope: prospective systematic guidelinebased evaluation of patients referred urgently to general hospitals. Eur Heart J. 2006;27(1):76–82. https://doi.org/10.1093/eurheartj/ehi647 DOI: https://doi.org/10.1093/eurheartj/ehi647