Brugada Syndrome or Phenocopy? Diagnostic Challenge in Patients with Pectus Excavatum
Abstract
Brugada syndrome is an autosomal dominant heart disease caused by dysfunctions in the ionic channels, whose carriers present a classic electrocardiographic pattern and predisposition to malignant ventricular arrhythmias. The electrocardiogram alterations may be dynamic, spontaneous, or induced by sodium channel blocking drugs (ajmaline, procainamide, etc.). However, electrocardiographic findings that diagnose Brugada syndrome may occur even in the absence of congenital dysfunction of ionic channels, characterizing “Brugada phenocopy”, therefore the exclusion of secondary causes is fundamental for the correct diagnosis of channelopathy.
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References
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implications. J Eletrocardiol. 2019;55:45-50. https://doi. org/10.1016/j.jelectrocard.2019.04.017
2. Dendramis G. Brugada syndrome and Brugada phenocopy. The importance of a differential diagnosis. Int J Cardiol.
2016;210:25-7. https://doi.org/10.1016/j.ijcard.2016.02.097
3. Awad SF, Barbosa-Barros R, Belem LS, Cavalcante CP, Riera AR, Garcia-Niebla J, et al. Brugada phenocopy in a patient
with pectus excavatum: systematic review of the ECG manifestations associated with pectus excavatum. Ann
Noninvasive Electrocardiol. 2013;18(5):415-20. https://doi. org/10.1111/anec.12082
4. Gottschalk BH, Anselm DD, Baranchuk A, Xu G. Brugada Phenocopy international registry and online educational
portal [Internet]. 2014 [cited 2019 Ago 24]. Available at: http://www.brugadaphenocopy.com
5. Marchetti M, Sierecki M, Oriot D, Ghazali A. Brugada-type ECG associated with pectus excavatum. Images Paediatr
Cardiol. 2015;17(3):1-2.
6. Abid I, Ewais MM, Marranca J, Jaroszewski DE. Pectus excavatum: A review of diagnosis and current treatment
options. J Am Osteopath Assoc. 2017;117(2):106-13. https:// doi.org/10.7556/jaoa.2017.021
7. Priori SG, Gasparini M, Napolitano C, Della BP, Ottonelli AG, Sassone B, et al. Risk stratification in Brugada syndrome:
results of the PRELUDE (PRogrammed ELectrical stimUlation preDictive valuE) registry. J Am Coll Cardiol. 2012;59:37-45.
https://doi.org/10.1016/j.jacc.2011.08.064
8. Kitamura T, Fukamizu S, Kawamura I, Hojo R, Aoyama Y, Nishizaki M, et al. Clinical characteristics and long-term prognosis of senior patients with Brugada syndrome. J Am Coll Cardiol. 2017;3(1):57-67. https://doi.org/10.1016/j.jacep.2016.04.004
9. Conte G, Asmundis C, Sieira J, Levinstein M, Chierchia GB, Giovanni G, et al. Clinical characteristics, management,
and prognosis of elderly patients with Brugada syndrome. J Cardiovasc Electrophysiol. 2014;25(5):514-19. https://doi.
org/10.1111/jce.12359
10. Kamakura T, Wada M, Nakajima I, Ishibashi K, Miyamoto K, Okamura H, et al. Evaluation of the necessity for cardioverter-defibrillator implantation in elderly patients with Brugada syndrome. Circ Arrhythm Electrophysiol. 2015;8(4):785-91. https://doi.org/10.1161/CIRCEP.114.002705
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Published
2020-01-17
How to Cite
Luciano, K. S. ., Goldoni, L. F. N. ., Sales, R. L. ., & Ronsoni, R. de M. . (2020). Brugada Syndrome or Phenocopy? Diagnostic Challenge in Patients with Pectus Excavatum. JOURNAL OF CARDIAC ARRHYTHMIAS, 32(3), 167–170. Retrieved from https://jca.org.br/jca/article/view/3299
Issue
Section
Clinical Arrythmia
