Congenital complete heart block

Characteristics of 34 patients submitted to definitive pacemaker implant or replacement

Authors

  • Iara Atié Malan
  • Andrea Rodrigues Viviani
  • Luiz Carlos Simões
  • Raizza Fernandes da Costa
  • Salem Dalla Bernardina Alcoforado Domingues
  • Marília Alcoforado Domingues
  • Alexandre Marques Abla
  • Gabriela de Mesquita Ferreira Bernardo

Keywords:

Pacemaker, Artificial, Atrioventricular Block, Heart Defects, Congenital

Abstract

Aims: Describe the characteristics of 34 patients under 18, with congenital complete heart block submitted for definitive pacemaker implant or replacement. Methods: We retrospectively analyzed patients who underwent pacemaker implant or replacement between January 2011 and May 2017 at a single center. The patients were divided into 2 groups (group I: implant and group II: replacement) and evaluated according to gender, age, congenital heart disease, implant indication, technique used, complications and mortality. Results: Thirty-four patients underwent definitive pacemaker implant or replacement, 47.1% of which were female. The median age at the time of implantation was 2 years and 6 months and median weight was 17.5 kg. Congenital heart disease was found in 52.9% of the patients. The indications for definitive pacemaker implant were heart rate lower than 70 bpm with heart disease or dysfunction (44.1%), heart rate less than 55 bpm without heart disease (26.5%), signs and  symptoms of low cardiac output (20.6%) and ventricular dysfunction (8.8%). The epicardial technique
was performed in 73.5% and the endocardial technique in 26.5% of the patients. A bicameral pacemaker was implanted in 53% and monocameral ventricular pacemaker in 47% of the patients. Complications were observed in 23.5%, with a mortality of 8.8% of the patients. Conclusions: The careful evaluation of the characteristics of these patients allows an adequate choice of the system and the implant technique. Just over half of the patients had congenital heart disease, the epicardial technique was the most performed, most received bicameral pacemaker, and complications and mortality were similar to the literature.

Downloads

Download data is not yet available.

References

1. Michaëlsson M, Engle MA. Congenital complete heart block: An international study of the natural history story. Cardiovasc Clin. 1972;4(3):85-101.

2. Buyon JP, Hiebert R, Copel J, Craft J, Friedman D, Katholi M, et al. Autoimmune-associated congenital heart block: demographics, mortality, morbidity and recurrence rates obtained from a national neonatal lupus registry. J Am Coll Cardiol. 1998;31(7):1658-66. DOI: https://doi.org/10.1016/S0735-1097(98)00161-2

3. Villain E, Coastedoat-Chalumeau N, Marijon E, Boudjemline Y, Piette JC, Bonnet D. Presentation and prognosis of complete atrioventricular block in childhood, according to maternal antibody status. J Am Coll Cardiol. 2006;48(8):1682-7. PMID: 17045907 DOI: https://doi.org/10.1016/j.jacc.2006.07.034

4. Villain E. Indications for pacing in patients with congenital heart disease. Pacing Clin Electrophysiol. 2008;31 Suppl 1:S17-20.

5. Yan J, Varma SK, Malhotra A, Menahem S. Congenital complete heart block: single tertiary centre experience. Heart Lung Circ. 2012;21(11):666-70. DOI: https://doi.org/10.1016/j.hlc.2012.05.784

6. Bordachar P, Zachary W, Ploux S, Labrousse L, Haissaguerre M, Thambo JB. Pathophysiology, clinical course, and management of congenital complete atrioventricular block. Heart Rhythm. 2013;10(5):760-6. DOI:https://doi.org/10.1016/j.hrthm.2012.12.030

7. Baruteau AE, Pass RH, Thambo JB, Behaghel A, Le Pennec S, Perdreau E, et al. Congenital and childhood atrioventricular blocks: pathophysiology and contemporary management. Eur J Pediatr. 2016;175(9):1235-48. DOI: https://doi.org/10.1007/s00431-016-2748-0

8. Wilhelm BJ, Thöne M, El-Scheich T, Livert D, Angelico R, Osswald B. Complications and Risk Assessment of 25 Years in Pediatric Pacing. Ann Thorac Surg. 2015;100(1):147-53. PMID: 25980596 DOI: https://doi.org/10.1016/j.athoracsur.2014.12.098

9. Takeuchi D, Tomizawa Y. Pacing device therapy in infants and children: a review. J Artif Organs. 2013;16(1):23-33. DOI: https://doi.org/10.1007/s10047-012-0668-y

10. Lotfy W, Hegazy R, AbdElAziz O, Sobhy R, Hasanein H, Shaltout F. Permanent cardiac pacing in pediatric patients. Pediatr Cardiol. 2013;34(2):273-80. DOI: https://doi.org/10.1007/s00246-012-0433-2

11. Zaidi S, Choi M, Wakimoto H, Ma L, Jiang J, Overton JD, et al. De novo mutations in histone-modifying genes in congenital heart disease. Nature. 2013;498(7453):220-3. DOI: https://doi.org/10.1038/nature12141

12. McCulley DJ, Black BL Transcription factor pathways and congenital heart disease. Curr Top Dev Biol. 2012;100:253-77. PMID: 22449847

13. Magalhães LP, Guimarães ICB, Melo SL, Mateo EIP, Andalaft RB, Xavier LFR, et al. Diretriz de Arritmias Cardíacas em Crianças e Cardiopatias Congênitas SOBRAC e DCC - CP. Arq Bras Cardiol. 2016;107(1 Supl 3):1-58.

14. Yildirim A, Tunaodlu FS, Karaadac AT. Neonatal congenital heart block. Indian Pediatr. 2013;50(5):483-8. DOI: https://doi.org/10.1007/s13312-013-0156-3

15. Kelle AM, Backer CL, Tsao S, Stewart RD, Franklin WH, Deal BJ, et al. Dualchamber epicardial pacing in neonates with congenital heart block. J Thorac Cardiovasc Surg. 2007;134(5):1188-92. PMID: 17976448 DOI: https://doi.org/10.1016/j.jtcvs.2007.04.049

16. Breur JM, Udink Ten Cate FE, Kapusta L, Cohen MI, Crosson JE, Boramanand N, et al. Pacemaker therapy in isolated congenital complete atrioventricular block. Pacing Clin Electrophysiol. 2002;25(12):1685-91. DOI: https://doi.org/10.1046/j.1460-9592.2002.01685.x

17. Karpawich PP, Perry BL, Farooki ZQ, Clapp SK, Jackson WL, Cicalese CA, et al. Pacing in children and young adults with nonsurgical atrioventricular block: comparison of single-rate ventricular and dualchamber modes. Am Heart J. 1987;113(2 Pt 1):316-21.

18. Silvetti MS, Drago F, De Santis A, Grutter G, Ravà L, Monti L, et al. Single-centre experience on endocardial and epicardial pacemaker system function in neonates and infants. Europace. 2007;9(6):426-31. DOI: https://doi.org/10.1093/europace/eum043

19. DeSimone CV, Friedman PA, Noheria A, Patel NA, DeSimone DC, Bdeir S, et al. Stroke or transient ischemic attack in patients with transvenous pacemaker or defibrillator and echocardiographically detected patent foramen ovale. Circulation. 2013;128(13):1433-41. PMID: 23946264 DOI: https://doi.org/10.1161/CIRCULATIONAHA.113.003540

20. Khairy P, Landzberg MJ, Gatzoulis MA, Mercier LA, Fernandes SM, Côté JM, et al.; Epicardial Versus ENdocardial pacing and Thromboembolic events Investigators. Transvenous pacing leads and systemic thromboemboli in patients with intracardiac shunts: a multicenter study. Circulation. 2006;113(20):2391-7. DOI: ttps://doi.org/10.1161/
CIRCULATIONAHA.106.622076

21. Olgun H, Karagoz T, Celiker A, Ceviz N. Patient- and lead-related factors affecting lead fracture in children with transvenous permanent pacemaker. Europace. 2008;10(7):844-7. DOI: https://doi.org/10.1093/europace/eun109

22. Murayama H, Maeda M, Sakurai H, Usui A, Ueda Y. Predictors affecting durability of epicardial pacemaker leads in pediatric patients. J Thorac Cardiovasc Surg. 2008;135(2):361-6. PMID: 18242269 DOI: https://doi.org/10.1016/j.jtcvs.2007.09.002

23. Pakarinen S, Oikarinen L, Toivonen L. Short-term implantation-related complications of cardiac rhythm management device therapy: a retrospective single-centre 1-year survey. Europace. 2010;12(1):103-8. DOI: https://doi.org/10.1093/europace/eup361

24. Chaouki AS, Spar DS, Khoury PR, Anderson JB, Knilans TK, Morales DL, et al. Risk factors for complications in the implantation of epicardial pacemakers in neonates and infants. Heart Rhythm. 2017;14(2):206-10. DOI: https://doi.org/10.1016/j.hrthm.2016.10.017

25. Schmidt KG, Ulmer HE, Silverman NH, Kleinman CS, Copel JA. Perinatal outcome of fetal complete atrioventricular block: a multicenter experience. J Am Coll Cardiol. 1991;17(6):1360-6. PMID: 2016455 DOI:https://doi.org/10.1016/S0735-1097(10)80148-2

Published

2018-10-01

How to Cite

Atié Malan, I., Rodrigues Viviani, A., Simões, L. C., Fernandes da Costa, R., Dalla Bernardina Alcoforado Domingues, S., Alcoforado Domingues, M., Marques Abla, A., & de Mesquita Ferreira Bernardo, G. (2018). Congenital complete heart block: Characteristics of 34 patients submitted to definitive pacemaker implant or replacement. JOURNAL OF CARDIAC ARRHYTHMIAS, 31(4), 160–166. Retrieved from https://jca.org.br/jca/article/view/100

Issue

Section

Cardiac Pacing

Categories